August 8, 2019

How FormDrop Changes Health and Healthcare for the World

Post by Calvin Wiese

Healthcare is information intensive; over 50% of healthcare cost is associated with the acquisition and management of information.  Kalibrate Blockchain is creating a fundamental inflection in the way information is acquired and used in healthcare. Most health issues are treated by users on themselves.  Users only access healthcare when they have exhausted their capabilities of treating themselves.  Great opportunity to improve health and healthcare exists in providing users better access to information they use to treat themselves. FormDrop equips users with richer and more useful tools to access, analyze and manage information about their health.  These resources are deployed in a manner that makes them clinically relevant; such that when users seek healthcare, this information is useful and relevant in the clinical context.  These resources bridge the gap between user treatment and clinical treatment such that both are more effective. The disease burden associated with lifestyle choices is rapidly increasing and reaching epidemic proportions.  There is an urgent and pressing need to motivate users to make better choices about their health.  Heart disease which is the #1 killer, and diabetes can be significantly reduced by lifestyle choices.  Cancer has strong associations with lifestyle.  Many infectious pathologies can be avoided or reduced through lifestyle behavior. Modification of lifestyle choices is almost never clinically employed as a treatment modality – largely because it is not effective. Clinicians are not equipped with effective tools for motiving lifestyle choices.  These tools are urgently needed! FormDrop is designed to create more effective tools for motivating healthy lifestyle choices.  It is conceived around the insight that the feedback loop from when a health destroying choice is made to when the body reports back a negative consequence is too long.  If that feedback loop can be shortened, better choices will be made.  Kalibrate Blockchain shortens this feedback loop by lowering the barriers of access to information written in blood where the negative consequence of health choices becomes evident sooner.  By making this information easily accessible to users, it will motivate users to make better choices about their health. There is information in blood that can motivate healthy choices when presented in manners that users can interpret; that’s what FormDrop does.  There is information in blood that can guide users in the treatment of their health; that’s what FormDrop does.  There is information in blood that can raise signals to users to seek clinical services; that’s what FormDrop does. Some of this information that is being developed for the FormDrop blood test includes:

  • Heart disease. Cardiac Troponin (high sensitivity). Any cardiac troponin detected in blood is a signal of cardiac necrosis (death of heart cells).  It always means that heart disease is present.  50% of the population has detectible cardiac troponin – most do not know it because it is not routinely tested due to the very high cost of this blood test using traditional methods. 

There are many pathologies that can cause cardiac necrosis, and the exact pathology may not be apparent when cardiac troponin is detected.  Regardless of pathology, exercise is always indicated when cardiac troponin is detected.   This can be used as a great motivator – everybody knows of someone who dropped dead from sudden cardiac arrest; almost certainly, trace levels of cardiac troponin is detectable prior to sudden cardiac arrest. 

Since 50% of the population has detectible levels of cardiac troponin, this blood test will raise signals that will be concerning to a lot of people.  This will cause significant demand for clinical consultations.  Doctors are not equipped to treat these indications.  Accordingly, FormDrop will partner with leading medical schools to develop appropriate protocols for doctors to utilize in response to these signals.  These protocols will be biased toward lifestyle modifications that will be directed toward reducing the levels of circulating cardiac protocol so that this signal will  be a  powerful motivator for these interventions.

  • Diabetes. HbA1c.  Vitamin B1.  FormDrop uses this information to motivate users to optimize the management of their diabetes and motivate users to make choices about their health to avoid onset of diabetes.  When users see this signal trending up toward diabetes, FormDrop will provide engaging edutainment designed to motivate lifestyle choices that will arrest the trend toward diabetes.  University of Essex and Warwick Medical School published that Vitamin B1 in plasma is up to 75% decreased in patients with diabetes, likely contributing to neuropathy, one of the earliest and most widespread adverse effects of diabetes. 
  • Inflammation. Heart disease.  C-Reactive Protein (CRP, high sensitivity).  C-reactive protein is a signal of inflammation and a signal of heart disease.  It is useful as a signal of inflammation that may need antibiotic treatment and as a signal for heart disease that may indicate the need for lifestyle modifications.
  • Breast Cancer. Vitamin D.  Vitamin D deficiency is implicated in many diseases.  University of California published their peer reviewed study demonstrating that breast cancer, the #3 cancer killer in America, survival rates are twice as high when Vitamin D levels are high at the time of diagnosis.  When FormDrop informs women of this study, they will want to be satisfied that their Vitamin D levels remain high.
  • Colon Cancer. Vitamin B9.  Tufts University School of Medicine published that this second most deadly cancer killer risk is reduced by up to 25% when Vitamin B9 supplementation is Just Right – it explains that when Vitamin B9 levels are low, colon cancer risk is increased, and that when Vitamin B9 levels are high, colon cancer risk is also increased.  “Not too much”, “Not too little”, but what it describes as the Goldlocks phenomena; “Just Right” is when colon cancer risk is reduced by up to 25%.
  • Anticoagulation. Native Prothrombin Antigen. Harvard Medical School published its study that demonstrates 85% reduction in adverse events associated with Coumadin therapy (high volume dangerous drug for anticoagulation) when monitored using Native Prothrombin Antigen instead of INR.  This makes anticoagulation therapy 6 times safer than any drug on the market today.

  • Tuberculosis. The burden of tuberculosis weighs heavily upon humanity; nearly 2 billion people are infected with the tuberculosis bacteria; the burden is heaviest in India, followed closely by China, Indonesia and Pakistan.  Its toll of suffering, death and economic cost is almost inestimable.  There are few needs more pressing on humanity than the management and elimination of tuberculosis.

    The tuberculosis bacteria is a persistent infection; once infected, it is almost not possible to clear from a host body.  Most of these infections are in a latent state where the host body is able to hold the bacteria in check and sufficiently suppress its activity to protect the host body.  Sometimes the host body loses control; the bacteria is able to overwhelm the defenses of the host and multiply into an active state.  Once in the active state, the bacteria can, and many does, kill the host body.  Also, while in the active state, the host body can infect other bodies through aerosol transmission.

    Efforts to lower the burden of tuberculosis on humanity continue.  These efforts are multi-faceted and continually evolving.  New strategies are needed.  Many strategies can be enhanced through better diagnosis.  The currently widely available diagnostics are primarily qualitative in nature; they signal the presence of the tuberculosis bacteria, but not the degree of infection.  Making quantitative diagnostics that signal the degree of infection widely accessible to the burdened populations would significantly enhance efforts to lower the burden.  Treatments could be targeted and dosed to the diverse conditions of each burdened host body. 

    There is significant evidence that proteins (glutamine synthetase and superoxide dismutase) excreted by the tuberculosis bacteria circulate in human blood in proportion to the degree of infection.  Quantifying these has been elusive because there are also human versions of these proteins in blood, and these proteins circulate in blood at low abundance.   High specificity (to distinguish between human and tuberculin species), high sensitivity (to quantify low abundance species) and high throughput (for low cost behavior) detection is needed.  FormDrop’s novel mass spectrometry method is exactly this.  FormDrop holds the great promise of providing this missing piece to the efforts to reduce the tuberculosis burden.  With FormDrop accessible to the burdened population, this promise becomes closer to humanity’s reach.

    FormDrop will provide these and other blood tests along with rich analytical tools and engaging edutainment to equip users to more effectively manage their health and motive healthy lifestyle choices.  This creates rich clinical information that clinicians will find relevant, important and useful in medical diagnosis and treatment.

    FormDrop is relevant to every human on earth.  It is sufficiently affordable so that it can be accessible to every human on earth.  For impoverished populations, it can be provided as an essential level of healthcare to every person.  FormDrop has the potential to make a significant impact on the health and healthcare of every person on earth.

    FormDrop is creating its in-silico biorepository that will become one of the most significant scientific assets to extend medical research.  A traditional biorepository is a biological materials storage facility that collects, processes, stores, and distributes biospecimens to support future scientific investigation.  Instead of storing actual biological specimens, FormDrop’s in-silico biorepository transcribes high-dimensional information from each blood specimen, storing it longitudinally and associating it with medical histories and clinical diagnostics recorded in users’ self-sovereign health records.  Instead of a few hundred or a few thousand entries, sample sizes in the millions will support the analysis of such high-dimensional data.   Mathematical methods for analyzing high dimensional in-silico biorepository data go beyond simple regression models commonly used in medical research. Regression models draw lines to classify very clean, carefully curated data. High-dimensional in-silico biorepository spaces are about classifying with multidimensional shapes using methods like those derived from the study of algebraic topology. Such tools enable rich, hypothesis-free explorations of this high-dimensional dataspace to search for the shapes for classifying the subtleties of massive, noisy, incomplete, biodiverse information like big data mining.  Under the leadership of Dr. Denise Kirschner, this scientific asset holds the potential of discovering fingerprints of disease that have long eluded medical research.  Such fingerprints hold the promise of earlier diagnosis of disease when treatment can be much more effective.

    Calvin Wiese   I President 

    Calvin Wiese is President of Kalibrate Blockchain.

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    You have such amazing article!

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    Kalibrate Blockchain.

    "The problem of tracking a patient's health information throughout their healthcare journey is one of the most significant healthcare problems, and that, when solved, holds the potential for a transformational inflection point for healthcare. This problem remains unsolved. We are here to bring hope."
    Calvin Wiese